John VI of the Leyen (German: Johann VI. von der Leyen) (c. 1510 - 10 February 1567) was the Archbishop of Trier from 1556 until 1567.

John was the son of Lord Bartholemew of the Leyen zu Saffig, the chancellor of the Archbishopric of Cologne. He was educated in Löwen, and gained office in the cathedral in Trier in 1528. As John also became a canon in Würzburg and Münster, he had enough money to further educate himself in Paris, Freiburg im Breisgau, Orléans and Padua. In 1535 he was made a chaplain in the cathedral at Trier, and in 1548 an Archdeacon. When Archbishop John V of Isenburg-Grenzau got sick in 1555, John was appointed by the cathedral chapter on the 22nd of October the coadjutor of the archbishopric.

After John of Isenburg-Grenzau died, John was elected the archbishop of Trier on 18 February 1556. At the Imperial Diet at Augsburg in 1559, John was strongly opposed to the abolition of the religious status quo. Caspar Olevian attempted to spread the reformation to Trier that year, but John successfully defeated him. As some neighbouring German states had adopted the Reformation, John replaced the entire 1560 strong teaching staff in the archdiocese with Jesuits. John's struggle with the reformation led to tensions with the city of Trier, and in 1560 controversy also erupted over the question of immediacy for the city of Coblenz. In order to continue to rule the latter, John had the old castle demolished.

John died in Coblenz in 1567 and was buried in the Florenskirche in Coblenz. When that was destroyed by the French in 1808 his remains were moved to the Leyen family crypt.

Preceded by:

John VI of the Leyen

Succeeded by:

John V of Isenburg-Grenzau Archbishop of Trier
1556 - 1567
Jacob III of Eltz