Berthold of Henneberg-Aschach-Römhild (1441/2–21 December 1504) was the Archbishop of Mainz from 1484 until 1504.

Berthold was the twelfth child of Count George of Henneberg-Aschach-Römhild. Berthold was educated in Cologne, Strasbourg and Bamberg. In 1464 he obtained office in the cathedral of Mainz. In 1472 he was made a member of the cathedral chapter, and in 1475 was made the cathedral deacon. Berthold later studied in Padua and Erfurt, and occasionally under Nicholas of Kues. Bertholf had also been active in the court of the Holy Roman Emperor Frederick III from 1467.

In 1484 Berthold was unanimously elected the Archbishop of Mainz, and he received confirmation by Pope Nicholas VIII on 20 September of that year. Berthold was focused on maintaining the secular borders of the prince-archbishopric as well as the maintenance of peace within it. Berthold also undertook much needed reform, promoted the University of Mainz, and in 1486 he wanted to introduce censorship to maintain Christian teaching but failed. In 1487 he held his first provincial synod. He personally took charge of the Imperial Chancellorship in 1494, and was active at the Diet of Worms in 1495 which established a new formal constitution of the Empire.

Bethold held his second and last provincial synod in 1499. The following year the Imperial Diet met for the first time under the new rules, and Berthold used his position as Chancellor to maintain peace at the proceedings of the first Reichsregiment. The Emperor Frederick III saw this as a vast reduction of his power and actively attempted to sabotage it, and it was dissolved in 1502 due to constant problems. Berthold died in 1504.

Preceded by:

Berthold of Henneberg-Aschach-Römhild

Succeeded by:

Adalbert III of Saxony Archbishop of Mainz
1484 - 1504
Jacob of Liebenstein